Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis.
نویسندگان
چکیده
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Osteoblast CFTR Inactivation Reduces Differentiation and Osteoprotegerin Expression in a Mouse Model of Cystic Fibrosis-Related Bone Disease
Low bone mass and increased fracture risk are recognized complications of cystic fibrosis (CF). CF-related bone disease (CFBD) is characterized by uncoupled bone turnover--impaired osteoblastic bone formation and enhanced osteoclastic bone resorption. Intestinal malabsorption, vitamin D deficiency and inflammatory cytokines contribute to CFBD. However, epidemiological investigations and animal ...
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ورودعنوان ژورنال:
- The European respiratory journal
دوره 39 3 شماره
صفحات -
تاریخ انتشار 2012